Triangulated Wireframe Structures Assembled Using Single-Stranded DNA Tiles

Michael Matthies, Nayan P. Agarwal, Erik Poppleton, Foram M. Joshi, Petr Šulc, Thorsten L. Schmidt

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The field of structural DNA nanotechnology offers a wide range of design strategies with which to build structures with a desired aspect ratio, size, and shape. Compared with traditional close-packed DNA structures, triangulated wireframe structures require less material per surface or volume unit and improve the stability in biologically relevant conditions due to the reduced electrostatic repulsion. Herein, we expand the design space of the DNA single-stranded tile method to cover a range of anisotropic, finite, triangulated wireframe structures as well as a number of one-dimensional crystalline assemblies. These structures are composed of six-arm junctions with a single double helix as connecting edges that assemble in physiologically relevant salinities. For a reliable folding of the structures, single-stranded spacers 2-4 nucleotides long have to be introduced in the junction connecting neighboring arms. Coarse-grained molecular dynamics simulations using the oxDNA model suggests that the spacers prevent the stacking of DNA helices, thereby facilitating the assembly of planar geometries.

Original languageEnglish (US)
Pages (from-to)1839-1848
Number of pages10
JournalACS nano
Issue number2
StatePublished - Feb 26 2019


  • Molecular dynamics simulations
  • Single-stranded tiles
  • Structural DNA nanotechnology
  • Triangulated wireframe structures

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


Dive into the research topics of 'Triangulated Wireframe Structures Assembled Using Single-Stranded DNA Tiles'. Together they form a unique fingerprint.

Cite this