Toward a realistic model of mutations affecting fitness

Peter D. Keightley, Michael Lynch

Research output: Contribution to journalShort surveypeer-review

107 Scopus citations


Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

Original languageEnglish (US)
Pages (from-to)683-685
Number of pages3
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes


  • Arabidopsis
  • Mutation
  • Mutation accumulation
  • Mutational effects distribution
  • Statistical inference

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)


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