The validity, stability, and utility of measuring uric acid in saliva

Jenna L. Riis, Crystal I. Bryce, Marla J. Matin, John L. Stebbins, Olga Kornienko, Lauren Van Huisstede, Douglas A. Granger

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.

Original languageEnglish (US)
Pages (from-to)583-596
Number of pages14
JournalBiomarkers in Medicine
Issue number6
StatePublished - Jun 2018


  • C-reactive protein
  • adiponectin
  • biomarker
  • body mass index
  • latent state-trait modeling
  • saliva
  • serum
  • uric acid

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical


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