The poxvirus C7L host range factor superfamily

Jia Liu, Stefan Rothenburg, Grant McFadden

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Host range factors, expressed by the poxvirus family, determine the host tropism of species, tissue, and cell specificity. C7L family members exist in the genomes of most sequenced mammalian poxviruses, suggesting an evolutionarily conserved effort adapting to the hosts. In general, C7L orthologs influence the host tropism in mammalian cell culture, and for some poxviruses it is essential for the complete viral life cycle in vitro and in vivo. The C7L family members lack obvious sequence homology with any other known viral or cellular proteins. Here we review recent findings from an evolutionary perspective and summarize recent progress that broadens our view on the role of C7L family members in mediating poxvirus host range and antagonizing the host defense system.

Original languageEnglish (US)
Pages (from-to)764-772
Number of pages9
JournalCurrent opinion in virology
Issue number6
StatePublished - Dec 2012
Externally publishedYes

ASJC Scopus subject areas

  • Virology


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