Abstract
Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of "smart" composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1186-1202 |
| Number of pages | 17 |
| Journal | Materials |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2010 |
Keywords
- Nanocomposite particles
- Pickering emulsion polymerization
- Temperature sensitivity
ASJC Scopus subject areas
- General Materials Science
- Condensed Matter Physics
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