TY - JOUR
T1 - The evolution of ERMIONE in mitochondrial biogenesis and lipid homeostasis
T2 - An evolutionary view from comparative cell biology
AU - Wideman, Jeremy G.
AU - Muñoz-Gómez, Sergio A.
N1 - Funding Information:
We would like to thank Frank Nargang for comments on an earlier draught of this manuscript. JGW is supported by European Molecular Biology Organization (EMBO) Long-term Fellowship (ALTF 761-2014 ) co-funded by European Commission ( EMBOCOFUND2012 , GA-2012-600394 ) support from Marie Curie Actions. SAM-G is supported by a Killam Pre-doctoral Scholarship.
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The ER-mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES and MICOS are two scaffolding complexes of ERMIONE that contribute to these processes. ERMES is ancient but has been lost in several lineages including animals, plants, and SAR (stramenopiles, alveolates and rhizaria). On the other hand, MICOS is ancient and has remained present in all organisms bearing mitochondrial cristae. The ERMIONE precursor evolved in the α-proteobacterial ancestor of mitochondria which had the central subunit of MICOS, Mic60. The subsequent evolution of ERMIONE and its interactors in eukaryotes reflects the integrative co-evolution of mitochondria and their hosts and the adaptive paths that some lineages have followed in their specialization to certain environments. By approaching the ERMIONE from a perspective of comparative evolutionary cell biology, we hope to shed light on not only its evolutionary history, but also how ERMIONE components may function in organisms other than S. cerevisiae. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
AB - The ER-mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES and MICOS are two scaffolding complexes of ERMIONE that contribute to these processes. ERMES is ancient but has been lost in several lineages including animals, plants, and SAR (stramenopiles, alveolates and rhizaria). On the other hand, MICOS is ancient and has remained present in all organisms bearing mitochondrial cristae. The ERMIONE precursor evolved in the α-proteobacterial ancestor of mitochondria which had the central subunit of MICOS, Mic60. The subsequent evolution of ERMIONE and its interactors in eukaryotes reflects the integrative co-evolution of mitochondria and their hosts and the adaptive paths that some lineages have followed in their specialization to certain environments. By approaching the ERMIONE from a perspective of comparative evolutionary cell biology, we hope to shed light on not only its evolutionary history, but also how ERMIONE components may function in organisms other than S. cerevisiae. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
KW - ERMES
KW - ERMIONE
KW - Evolutionary cell biology
KW - MCS
KW - MICOS
KW - Membrane contact sites
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U2 - 10.1016/j.bbalip.2016.01.015
DO - 10.1016/j.bbalip.2016.01.015
M3 - Review article
C2 - 26825688
AN - SCOPUS:84974577792
SN - 1388-1981
VL - 1861
SP - 900
EP - 912
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 8
ER -