The CpxR/CpxA Two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide

Natasha Weatherspoon-Griffin; Dezhi Yang; Wei Kong; Zichun Hua; Yixin Shi

doi:10.1074/jbc.M114.565762

The CpxR/CpxA Two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide

Natasha Weatherspoon-Griffin, Dezhi Yang, Wei Kong, Zichun Hua, Yixin Shi

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Background: The CpxR/CpxA system facilitates E. coli resistance to antimicrobial peptides. However, many CpxR-dependent mechanisms remain elusive.

Results: The CpxR/CpxA system activates mar transcription, subsequently facilitating E. coli resistance to protamine via tripartite multidrug transporters.

Conclusion: A CpxR/CpxA-dependent regulatory cascade controls MarRA for CAMP resistance in response to aromatic metabolites.

Significance: This is novel regulatory mechanism controlling bacterial resistance to CAMPs and antibiotics.

Original language	English (US)
Pages (from-to)	32571-32582
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M114.565762
State	Published - Nov 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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The CpxR/CpxA Two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide. / Weatherspoon-Griffin, Natasha; Yang, Dezhi; Kong, Wei et al.
In: Journal of Biological Chemistry, Vol. 289, No. 47, 21.11.2014, p. 32571-32582.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: The CpxR/CpxA system facilitates E. coli resistance to antimicrobial peptides. However, many CpxR-dependent mechanisms remain elusive.Results: The CpxR/CpxA system activates mar transcription, subsequently facilitating E. coli resistance to protamine via tripartite multidrug transporters.Conclusion: A CpxR/CpxA-dependent regulatory cascade controls MarRA for CAMP resistance in response to aromatic metabolites.Significance: This is novel regulatory mechanism controlling bacterial resistance to CAMPs and antibiotics.",

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AU - Hua, Zichun

AU - Shi, Yixin

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The CpxR/CpxA Two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide

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