The chemistry of toxic principles from Maytenus nemerosa

Fang Sheng-Ding, David E. Berry, David G. Lynn, Sidney M. Hecht, James Campbell, William S. Lynn

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Maytenus nemerosa has been fractionated systematically by following the toxicity of extracts, partitioned solutions and column chromatographic fractions against cultured KB cells. Several compounds were isolated in this fashion, including 3-oxo-20(29)-lupen-30-al, β-amyrin, 29-hydroxyfriedelan-3-one, 30-hydroxy-20(29)-lupen-3-one, 30-hydroxyfriedelan-3-one and lup-20(29)-ene-3β,30-diol, as well as tingenone, 20-hydroxytingenone and galactitol. 3-Oxo-20(29)-lupen-30-al was shown to be cytotoxic for the first time; the structural basis of this cytotoxicity was investigated, in part, by bioassay of four products obtained by chemical transformation of single, isolated principles.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
Issue number3
StatePublished - 1984
Externally publishedYes


  • Celastraceae
  • Maytenus nemerosa
  • antineoplastic agents
  • cytotoxic principles
  • pentacyclic triterpenes.

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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