Testosterone and opioids interact to regulate feeding in a male migratory songbird

Pierre Deviche

doi:10.1016/0018-506X(92)90009-K

Testosterone and opioids interact to regulate feeding in a male migratory songbird

Pierre Deviche

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A male migratory songbird (dark-eyed junco, Junco hyemalis) was used as a model for studies on the influence of testosterone (T) on feeding, and on interactive effects on this behavior between T and the opioid antagonist naloxone hydrochloride (Nal). Administered chronically to birds exposed to nonstimulating photoperiods, T increased food intake by 30-58% without altering the body mass, the fat index, or the standard metabolic rate. An intramuscular injection of Nal decreased feeding temporarily in a dose-related manner. T-treated juncos exhibited a decreased sensitivity to the anorexic influence of Nal administration, demonstrating that T interacts with opioids to control food consumption. Neuroendocrine mechanisms that potentially account for this interaction are discussed.

Original language	English (US)
Pages (from-to)	394-405
Number of pages	12
Journal	Hormones and Behavior
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/0018-506X(92)90009-K
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1016/0018-506X(92)90009-K

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title = "Testosterone and opioids interact to regulate feeding in a male migratory songbird",

abstract = "A male migratory songbird (dark-eyed junco, Junco hyemalis) was used as a model for studies on the influence of testosterone (T) on feeding, and on interactive effects on this behavior between T and the opioid antagonist naloxone hydrochloride (Nal). Administered chronically to birds exposed to nonstimulating photoperiods, T increased food intake by 30-58\% without altering the body mass, the fat index, or the standard metabolic rate. An intramuscular injection of Nal decreased feeding temporarily in a dose-related manner. T-treated juncos exhibited a decreased sensitivity to the anorexic influence of Nal administration, demonstrating that T interacts with opioids to control food consumption. Neuroendocrine mechanisms that potentially account for this interaction are discussed.",

author = "Pierre Deviche",

note = "Funding Information: It is a pleasuret o thank Dr. Kent Schwaegerlef or help with the statisticala nalyses.T he work was supportedb y a UAF Faculty Small Grant to the author.",

year = "1992",

month = sep,

doi = "10.1016/0018-506X(92)90009-K",

language = "English (US)",

volume = "26",

pages = "394--405",

journal = "Hormones and Behavior",

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AU - Deviche, Pierre

N1 - Funding Information: It is a pleasuret o thank Dr. Kent Schwaegerlef or help with the statisticala nalyses.T he work was supportedb y a UAF Faculty Small Grant to the author.

PY - 1992/9

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N2 - A male migratory songbird (dark-eyed junco, Junco hyemalis) was used as a model for studies on the influence of testosterone (T) on feeding, and on interactive effects on this behavior between T and the opioid antagonist naloxone hydrochloride (Nal). Administered chronically to birds exposed to nonstimulating photoperiods, T increased food intake by 30-58% without altering the body mass, the fat index, or the standard metabolic rate. An intramuscular injection of Nal decreased feeding temporarily in a dose-related manner. T-treated juncos exhibited a decreased sensitivity to the anorexic influence of Nal administration, demonstrating that T interacts with opioids to control food consumption. Neuroendocrine mechanisms that potentially account for this interaction are discussed.

AB - A male migratory songbird (dark-eyed junco, Junco hyemalis) was used as a model for studies on the influence of testosterone (T) on feeding, and on interactive effects on this behavior between T and the opioid antagonist naloxone hydrochloride (Nal). Administered chronically to birds exposed to nonstimulating photoperiods, T increased food intake by 30-58% without altering the body mass, the fat index, or the standard metabolic rate. An intramuscular injection of Nal decreased feeding temporarily in a dose-related manner. T-treated juncos exhibited a decreased sensitivity to the anorexic influence of Nal administration, demonstrating that T interacts with opioids to control food consumption. Neuroendocrine mechanisms that potentially account for this interaction are discussed.

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Testosterone and opioids interact to regulate feeding in a male migratory songbird

Abstract

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