Temporally Adaptive-Dynamic Sparse Network for Modeling Disease Progression

Jie Zhang, Yalin Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Alzheimer's disease (AD) is a neurodegenerative disorder with progressive impairment of memory and cognitive functions. Sparse coding (SC) has been demonstrated to be an efficient and effective method for AD diagnosis and prognosis. However, previous SC methods usually focus on the baseline data while ignoring the consistent longitudinal features with strong sparsity pattern along the disease progression. Additionally, SC methods extract sparse features from image patches separately rather than learn with the dictionary atoms across the entire subject. To address these two concerns and comprehensively capture temporal-subject sparse features towards earlier and better discriminability of AD, we propose a novel supervised SC network termed Temporally Adaptive-Dynamic Sparse Network (TADsNet) to uncover the sequential correlation and native subject-level codes from the longitudinal brain images. Our work adaptively updates the sparse codes to impose the temporal regularized correlation and dynamically mine the dictionary atoms to make use of entire subject-level features. Experimental results on ADNI-I cohort validate the superiority of our approach.

Original languageEnglish (US)
Title of host publicationISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Number of pages5
ISBN (Electronic)9781538693308
StatePublished - Apr 2020
Event17th IEEE International Symposium on Biomedical Imaging, ISBI 2020 - Iowa City, United States
Duration: Apr 3 2020Apr 7 2020

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Conference17th IEEE International Symposium on Biomedical Imaging, ISBI 2020
Country/TerritoryUnited States
CityIowa City


  • Longitudinal
  • RNN
  • Sparse Coding

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Temporally Adaptive-Dynamic Sparse Network for Modeling Disease Progression'. Together they form a unique fingerprint.

Cite this