Telomeres and Telomerase

Julian J.L. Chen; Dhenugen Logeswaran; Joshua D. Podlevsky

doi:10.1016/B978-0-12-821618-7.00098-5

Telomeres and Telomerase

Julian J.L. Chen
, Dhenugen Logeswaran
, Joshua D. Podlevsky

Molecular Sciences, School of (SMS)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Eukaryotic genomes are organized into linear chromosomes which require unique systems for protecting the ends. Telomeres are end-capping structures that prevent chromosome termini from undesirable fusion events. The integrity and length of telomeres are crucial for chromosome stability. Telomere integrity is maintained by telomeric proteins that specifically coat and protect telomeric DNA. The length of telomeric DNA is maintained by the telomerase enzyme that synthesizes telomeric DNA repeats onto chromosome ends from a short template sequence within its integral RNA component. Mutations that negatively affect telomerase, telomere integrity or length, result in chromosome instability, cell death, and human diseases.

Original language	English (US)
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	511-522
Number of pages	12
Volume	1
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00098-5
State	Published - Jan 1 2022

Keywords

Ageing
Cancer
Chromosome ends
Chromosome fusions
Dyskerin
End replication problem
Lagging strand
Leading strand
Reverse transcriptase
ScaRNA
Short telomere syndromes
SnoRNA

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-821618-7.00098-5

Cite this

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abstract = "Eukaryotic genomes are organized into linear chromosomes which require unique systems for protecting the ends. Telomeres are end-capping structures that prevent chromosome termini from undesirable fusion events. The integrity and length of telomeres are crucial for chromosome stability. Telomere integrity is maintained by telomeric proteins that specifically coat and protect telomeric DNA. The length of telomeric DNA is maintained by the telomerase enzyme that synthesizes telomeric DNA repeats onto chromosome ends from a short template sequence within its integral RNA component. Mutations that negatively affect telomerase, telomere integrity or length, result in chromosome instability, cell death, and human diseases.",

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AU - Podlevsky, Joshua D.

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N2 - Eukaryotic genomes are organized into linear chromosomes which require unique systems for protecting the ends. Telomeres are end-capping structures that prevent chromosome termini from undesirable fusion events. The integrity and length of telomeres are crucial for chromosome stability. Telomere integrity is maintained by telomeric proteins that specifically coat and protect telomeric DNA. The length of telomeric DNA is maintained by the telomerase enzyme that synthesizes telomeric DNA repeats onto chromosome ends from a short template sequence within its integral RNA component. Mutations that negatively affect telomerase, telomere integrity or length, result in chromosome instability, cell death, and human diseases.

AB - Eukaryotic genomes are organized into linear chromosomes which require unique systems for protecting the ends. Telomeres are end-capping structures that prevent chromosome termini from undesirable fusion events. The integrity and length of telomeres are crucial for chromosome stability. Telomere integrity is maintained by telomeric proteins that specifically coat and protect telomeric DNA. The length of telomeric DNA is maintained by the telomerase enzyme that synthesizes telomeric DNA repeats onto chromosome ends from a short template sequence within its integral RNA component. Mutations that negatively affect telomerase, telomere integrity or length, result in chromosome instability, cell death, and human diseases.

KW - Ageing

KW - Cancer

KW - Chromosome ends

KW - Chromosome fusions

KW - Dyskerin

KW - End replication problem

KW - Lagging strand

KW - Leading strand

KW - Reverse transcriptase

KW - ScaRNA

KW - Short telomere syndromes

KW - SnoRNA

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DO - 10.1016/B978-0-12-821618-7.00098-5

M3 - Chapter

AN - SCOPUS:85158985540

VL - 1

SP - 511

EP - 522

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Telomeres and Telomerase

Abstract

Keywords

ASJC Scopus subject areas

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