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Synthesis and characterization of a hypoxia-sensitive MRI probe
Federico A. Rojas-Quijano
, Gyula Tircsõ
, Enikó Tircsõné Benyõ
, Zsolt Baranyai
, Huan Tran Hoang
, Ferenc K. Kálmán
, Praveen K. Gulaka
,
Vikram D. Kodibagkar
, Silvio Aime
, Zoltán Kovács
, A. Dean Sherry
Research output
:
Contribution to journal
›
Article
›
peer-review
48
Scopus citations
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Keyphrases
Normoxic
100%
MRI Probe
100%
Hypoxia-sensitive
100%
Nitroimidazole Derivatives
75%
Hypoxic Cells
75%
DO3A
75%
Monoamide
50%
2-nitroimidazole
50%
Water Protons
50%
Rat Glioma Cells
50%
T1 Relaxation Time
50%
Proton
25%
Side Chain
25%
Immediate Effect
25%
Imaging Methods
25%
Magnetic Resonance Imaging
25%
Oxygen Supply
25%
Variable Temperature
25%
Heart Stroke
25%
Hypoxia
25%
MRI Techniques
25%
Imaging Experiment
25%
Thermodynamic Stability
25%
Molecular Size
25%
Control Complex
25%
Ischemic Heart Disease
25%
Oxygen Demand
25%
Measurement Variables
25%
MRI Contrast Agent
25%
Bound Water
25%
Gd3+
25%
1,4,7,10-tetraazacyclododecane
25%
Rotational Correlation Time
25%
Amide Derivatives
25%
17O NMR Spectroscopy
25%
Therapy Choice
25%
Tissue Hypoxia
25%
Molecular Reporters
25%
Nitroimidazole
25%
Gd-DOTA
25%
Ex Vivo MRI
25%
Gadolinium(III) Complex
25%
Amide Linkage
25%
Dispersion Study
25%
Pathologic Conditions
25%
Relaxivity
25%
Carboxyl Group
25%
Nuclear Magnetic Relaxation Dispersion
25%
Pharmacology, Toxicology and Pharmaceutical Science
Hypoxia
100%
Tetraxetan
100%
Nitroimidazole Derivative
100%
Carboxamide
66%
2 Nitroimidazole
66%
Malignant Neoplasm
33%
Ischemic Heart Disease
33%
Hypoxemia
33%
Gadolinium
33%
Oxygen 17
33%
Carboxyl Group
33%
Nitroimidazole
33%
Cerebrovascular Accident
33%
Chemistry
Magnetic Resonance Imaging
100%
Carboxamide
33%
DOTA
33%
2-Nitroimidazole
33%
stability
33%
1,4,7,10-tetraazacyclododecane
16%
Rotational Correlation Time
16%
Molecular Size
16%
Biochemical Oxygen Demand
16%
17O NMR Spectroscopy
16%
Gadolinium
16%
Magnetic Relaxation
16%