Synthesis and biological evaluation of fully synthetic bryostatin analogues

Paul A. Wender, Jef De Brabander, Patrick G. Harran, Kevin W. Hinkle, Blaise Lippa, George Pettit

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)8625-8628
Number of pages4
JournalTetrahedron Letters
Issue number47
StatePublished - Nov 19 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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