Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Ali Cagir; Shannon H. Jones; Brian M. Eisenhauer; Rong Gao; Sidney M. Hecht

doi:10.1016/j.bmcl.2004.02.069

Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Ali Cagir
, Shannon H. Jones
, Brian M. Eisenhauer
, Rong Gao
, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

Original language	English (US)
Pages (from-to)	2051-2054
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.069
State	Published - May 3 2004
Externally published	Yes

Keywords

Antineoplastic agents
Cytotoxic alkaloids
Topoisomerase I poisons

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.02.069

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title = "Synthesis and biochemical properties of E-ring modified luotonin a derivatives",

abstract = "Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.",

keywords = "Antineoplastic agents, Cytotoxic alkaloids, Topoisomerase I poisons",

author = "Ali Cagir and Jones, \{Shannon H.\} and Eisenhauer, \{Brian M.\} and Rong Gao and Hecht, \{Sidney M.\}",

note = "Funding Information: We thank Dr. Mary-Ann Bjornsti, St. Jude Children's Hospital, for the yeast strain used for evaluation of luotonin derivatives. This work was supported by NIH Research Grant CA78415 awarded by the National Cancer Institute.",

year = "2004",

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doi = "10.1016/j.bmcl.2004.02.069",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and biochemical properties of E-ring modified luotonin a derivatives

AU - Cagir, Ali

AU - Jones, Shannon H.

AU - Eisenhauer, Brian M.

AU - Gao, Rong

AU - Hecht, Sidney M.

N1 - Funding Information: We thank Dr. Mary-Ann Bjornsti, St. Jude Children's Hospital, for the yeast strain used for evaluation of luotonin derivatives. This work was supported by NIH Research Grant CA78415 awarded by the National Cancer Institute.

PY - 2004/5/3

Y1 - 2004/5/3

N2 - Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

AB - Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

KW - Antineoplastic agents

KW - Cytotoxic alkaloids

KW - Topoisomerase I poisons

UR - https://www.scopus.com/pages/publications/1842640171

UR - https://www.scopus.com/pages/publications/1842640171#tab=citedBy

U2 - 10.1016/j.bmcl.2004.02.069

DO - 10.1016/j.bmcl.2004.02.069

M3 - Article

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SN - 0960-894X

VL - 14

SP - 2051

EP - 2054

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Abstract

Keywords

ASJC Scopus subject areas

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