Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Theresa A. Jones; Jeffrey A. Kleim; William T. Greenough

doi:10.1016/0006-8993(96)00792-5

Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Theresa A. Jones, Jeffrey A. Kleim, William T. Greenough

Research output: Contribution to journal › Article › peer-review

200 Scopus citations

Abstract

Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

Original language	English (US)
Pages (from-to)	142-148
Number of pages	7
Journal	Brain Research
Volume	733
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(96)00792-5
State	Published - Sep 9 1996
Externally published	Yes

Keywords

Forelimb behavior
Layer V
Motor cortex
Motor learning
Restoration of function
Stereology
Synaptic plasticity

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(96)00792-5

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abstract = "Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.",

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T2 - A quantitative electron microscopic examination

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AU - Kleim, Jeffrey A.

AU - Greenough, William T.

PY - 1996/9/9

Y1 - 1996/9/9

N2 - Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

AB - Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.

KW - Forelimb behavior

KW - Layer V

KW - Motor cortex

KW - Motor learning

KW - Restoration of function

KW - Stereology

KW - Synaptic plasticity

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Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: A quantitative electron microscopic examination

Abstract

Keywords

ASJC Scopus subject areas

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