Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C.W. Smith, Yonatan M. Kupchik, Michael D. Scofield, Cassandra D. Gipson, Armina Wiggins, Charles A. Thomas, Peter W. Kalivas

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)1655-1657
Number of pages3
JournalNature Neuroscience
Issue number12
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases'. Together they form a unique fingerprint.

Cite this