Survival benefit of solid-organ transplant in the United States

Abbas Rana, Angelika Gruessner, Vatche G. Agopian, Zain Khalpey, Irbaz B. Riaz, Bruce Kaplan, Karim J. Halazun, Ronald W. Busuttil, Rainer W.G. Gruessner

    Research output: Contribution to journalArticlepeer-review

    356 Scopus citations


    Importance: The field of transplantation has made tremendous progress since the first successful kidney transplant in 1954. Objective: To determine the survival benefit of solid-organ transplant as recorded during a 25-year study period in the United Network for Organ Sharing (UNOS) database and the Social Security Administration Death Master File. Design, Setting, And Participants: In this retrospective analysis of UNOS data for solid-organ transplant during a 25-year period (September 1, 1987, through December 31, 2012), we reviewed the records of 1 112 835 patients: 533 329 recipients who underwent a transplant and 579 506 patients who were placed on the waiting list but did not undergo a transplant. Main Outcomes And Measures: The primary outcomewas patient death while on the waiting list or after transplant. Kaplan-Meier survival functions were used for time-to-event analysis. Results: We found that 2 270 859 life-years (2 150 200 life-years from the matched analysis) were saved to date during the 25 years of solid-organ transplant. A mean of 4.3 life-years were saved (observed to date) per solid-organ transplant recipient. Kidney transplant saved 1 372 969 life-years; liver transplant, 465 296 life-years; heart transplant, 269 715 life-years; lung transplant, 64 575 life-years; pancreas-kidney transplant, 79 198 life-years; pancreas transplant, 14 903 life-years; and intestine transplant, 4402 life-years. Conclusions And Relevance: Our analysis demonstrated that more than 2 million life-years were saved to date by solid-organ transplants during a 25-year study period. Transplants should be supported and organ donation encouraged.

    Original languageEnglish (US)
    Pages (from-to)252-259
    Number of pages8
    JournalJAMA Surgery
    Issue number3
    StatePublished - Mar 1 2015

    ASJC Scopus subject areas

    • Surgery


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