Surface plasmon resonance mass spectrometry: Recent progress and outlooks

Dobrin Nedelkov, Randall W. Nelson

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


The combination of surface plasmon resonance (SPR) and mass spectrometry (MS) has created a unique approach to protein investigations. Surface plasmon resonance is used to quantify interactions between proteins and surface-immobilized ligands, and MS is used to determine the structural features of the bound proteins. Recent progress in SPR-MS includes improved methods and operations, increased limits of detection, multi-protein analysis and protein-complex delineation. With the subsequent design of SPR protein arrays, SPR-MS is expected to enter into the field of high-throughput protein interaction discovery and miniaturized diagnostics.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalTrends in Biotechnology
Issue number7
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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