STRUCTURAL BIOCHEMISTRY 17. Synthesis of Tryptophan Dipeptides

George Pettit; T. S. Krupa; R. M. Reynolds

doi:10.1111/j.1399-3011.1979.tb01925.x

STRUCTURAL BIOCHEMISTRY 17. Synthesis of Tryptophan Dipeptides

George Pettit, T. S. Krupa, R. M. Reynolds

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Boc‐Trp‐Leu hydrazide has been found to significantly inhibit growth of the L‐1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI‐NHS peptide bond‐forming procedure.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	International Journal of Peptide and Protein Research
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3011.1979.tb01925.x
State	Published - Sep 1979

Keywords

antineoplastic activity
tryptophan dipeptides

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1979.tb01925.x

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title = "STRUCTURAL BIOCHEMISTRY 17. Synthesis of Tryptophan Dipeptides",

abstract = "Boc‐Trp‐Leu hydrazide has been found to significantly inhibit growth of the L‐1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI‐NHS peptide bond‐forming procedure.",

keywords = "antineoplastic activity, tryptophan dipeptides",

author = "George Pettit and Krupa, {T. S.} and Reynolds, {R. M.}",

year = "1979",

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AU - Pettit, George

AU - Krupa, T. S.

AU - Reynolds, R. M.

PY - 1979/9

Y1 - 1979/9

N2 - Boc‐Trp‐Leu hydrazide has been found to significantly inhibit growth of the L‐1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI‐NHS peptide bond‐forming procedure.

AB - Boc‐Trp‐Leu hydrazide has been found to significantly inhibit growth of the L‐1210 and P388 murine lymphocytic leukemias. A series of related tryptophan dipeptides were prepared and found to be devoid of such activity. The tryptophan dipeptides were most conveniently obtained employing the DCCI‐NHS peptide bond‐forming procedure.

KW - antineoplastic activity

KW - tryptophan dipeptides

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DO - 10.1111/j.1399-3011.1979.tb01925.x

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JF - International Journal of Peptide and Protein Research

IS - 3

ER -

STRUCTURAL BIOCHEMISTRY 17. Synthesis of Tryptophan Dipeptides

Abstract

Keywords

ASJC Scopus subject areas

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