Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

John C. Hornberger, Stephen J. Buell, Dorothy G. Flood, Thomas H. McNeill, Paul D. Coleman

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


In normal mammalian aging there is a reduction of cholinergic markers in a variety of regions. To determine whether this reduction is related to reduced numbers of basal forebrain cholinergic neurons, we counted the number and measured the sizes of the magnocellular acetylcholinesterase-positive neurons in this region of 7, 15, and 53-month-old C57B1/6NNIA mice. Data were collected from coded slides containing the medial septum, nucleus of the diagonal band, magnocellular preoptic nucleus, and nucleus basalis magnocellularis. There was no decline in numbers of basal forebrain acetylcholinesterasepositive neurons in any of the regions studied. However, cell sizes showed a progressive age-related decline which was greatest in the nucleus basalis magnocellularis.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalNeurobiology of Aging
Issue number4
StatePublished - 1985
Externally publishedYes


  • Acetylcholinesterase
  • Aging
  • Basal forebrain
  • Cell numbers
  • Cell sizes
  • Cholinergic neurons
  • Magnocellular preoptic area
  • Mouse
  • Nucleus basalis of Meynert
  • Nucleus of the diagonal band of Broca
  • Substantia innominata

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


Dive into the research topics of 'Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months'. Together they form a unique fingerprint.

Cite this