Single molecule diffraction

John Spence, R. B. Doak

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


For solving the atomic structure of organic molecules such as small proteins which are difficult to crystallize, the use of a jet of doped liquid helium droplets traversing a continuous high energy electron beam is proposed as a means of obtaining electron diffraction patterns (serial crystallography). Organic molecules (such as small proteins) within the droplet (and within a vitreous ice jacket) may be aligned by use of a polarized laser beam. Iterative methods for solving the phase problem are indicated. Comparisons with a related plan for pulsed x-ray diffraction from single proteins in a molecular beam are provided.

Original languageEnglish (US)
Number of pages1
JournalPhysical Review Letters
Issue number19
StatePublished - May 14 2004

ASJC Scopus subject areas

  • General Physics and Astronomy


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