Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory

Brittany Braden, Kara B. Dassel, Heather Bimonte-Nelson, Holly O'Rourke, Donald J. Connor, Sallie Moorhous, Marwan N. Sabbagh, Richard J. Caselli, Leslie C. Baxter

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Many studies suggest sex differences in memory and hippocampal size, and that hormone therapy (HT) may positively affect these measures in women; however, the parameters of HT use that most likely confer benefits are debated. We evaluated the impact of sex and postmenopausal HT use on verbal learning and memory and hippocampal size in 94 cognitively intact women and 49 men. Using analysis of covariance that controlled for age and education, women had better total word learning and delayed verbal memory performance than men. HT analyses showed that non-HT users performed similarly to men, while HT users performed better than men in Delayed Memory regardless of whether use was current or in the past. Women had larger hippocampal volumes than men regardless of whether they were HT users. Using univariate linear models, we assessed group differences in the predictive value of hippocampal volumes for verbal learning and memory. Hippocampal size significantly predicted memory performance for men and non-HT users, but not for HT users. This lack of relationship between hippocampal size and verbal learning and memory performance in HT users suggests HT use may impact memory through extra-hippocampal neural systems.

Original languageEnglish (US)
Pages (from-to)227-246
Number of pages20
JournalAging, Neuropsychology, and Cognition
Issue number3
StatePublished - May 4 2017


  • Aging
  • cognition
  • hippocampal volume
  • hormone therapy
  • sex

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory'. Together they form a unique fingerprint.

Cite this