Semaphorins 4A and 4D in chronic inflammatory diseases

Svetlana P. Chapoval, Zahava Vadasz, Andrei Chapoval, Elias Toubi

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalInflammation Research
Issue number2
StatePublished - Feb 1 2017


  • Asthma
  • Autoimmune diseases
  • Cancer
  • Chronic inflammation
  • Semaphorins

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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