Selfassembly of metallic nanoparticle arrays by DNA scaffolding

Shoujun Xiao, Furong Liu, Abbey E. Rosen, James F. Hainfeld, Nadrian C. Seeman, Karin Musier-Forsyth, Richard A. Kiehl

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


We report the self-assembly of metallic nanoparticle arrays using DNA crystals as a programmable molecular scaf-folding. Gold nanoparticles, 1.4 nm in diameter, are assembled in two-dimensional arrays with interparticle spacings of 4 and 64 nm. The nanoparticles form precisely integrated components, which are covalently bonded to the DNA scaffolding. These results show that heterologous chemical systems can be assembled into precise, programmable geometrical arrangements by DNA scaffolding, thereby representing a critical step toward the realization of DNA nanotechnology.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalJournal of Nanoparticle Research
Issue number4
StatePublished - 2002
Externally publishedYes


  • DNA
  • Nanoelectronics
  • Nanoparticles
  • Nanotechnology
  • Self-assembly

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics
  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • General Materials Science
  • Modeling and Simulation


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