Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin; Evaldas Katilius; Yan Liu; Hao Yan

Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin, Evaldas Katilius, Yan Liu, Hao Yan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

Original language	English (US)
Title of host publication	3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
Pages	161-162
Number of pages	2
State	Published - 2006
Event	3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 - Snowbird, UT, United States Duration: Apr 23 2006 → Apr 27 2006

Other

Other	3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
Country/Territory	United States
City	Snowbird, UT
Period	4/23/06 → 4/27/06

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

Cite this

@inproceedings{05ba96b13a4642b692d899362dc36518,

title = "Self-assembled signaling aptamer DNA arrays for protein detection",

abstract = "Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.",

author = "Chenxiang Lin and Evaldas Katilius and Yan Liu and Hao Yan",

year = "2006",

language = "English (US)",

pages = "161--162",

booktitle = "3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006",

note = "3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 ; Conference date: 23-04-2006 Through 27-04-2006",

}

TY - GEN

T1 - Self-assembled signaling aptamer DNA arrays for protein detection

AU - Lin, Chenxiang

AU - Katilius, Evaldas

AU - Liu, Yan

AU - Yan, Hao

PY - 2006

Y1 - 2006

N2 - Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

AB - Here we report a DNA tile directed self-assembly of signaling aptamers into high-density nanoarrays for highly sensitive detection of protein molecules. The high local density of the signaling aptamers displayed on the self-assembled DNA arrays allowed us to detect sub-nanomolar concentrations of protein bound to the aptamers using confocal fluorescence microscope imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

UR - http://www.scopus.com/inward/record.url?scp=84874697527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874697527&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84874697527

SP - 161

EP - 162

BT - 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006

T2 - 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006

Y2 - 23 April 2006 through 27 April 2006

ER -

Self-assembled signaling aptamer DNA arrays for protein detection

Abstract

Other

ASJC Scopus subject areas

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