Search for Peptides Specifically Binding with the B7-2 Costimulatory Molecule

E. A. Kolosova, O. E. Viktorina, A. I. Chapoval, D. N. Shcherbakov

Research output: Contribution to journalArticlepeer-review


Abstract—: The interaction of B7-1/B7-2 ligands with CD28/CTLA-4 receptors plays a key role in the regulation of the immune response. The aim of this study was to find and study peptides that interact with the human B7-2 molecule. In the course of the work, three rounds of affinity selection were carried out and individual phage clones were selected, which include peptides with varying degrees of interaction with the coregulatory target B7-2. As a result of DNA sequencing of selected phages, nucleotide sequences encoding peptides that specifically bind to B7-2 were obtained. The identified peptides can be used as a basis for the development of immunotherapeutic drugs for regulating the immune response in the treatment of oncological diseases.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalRussian Journal of Bioorganic Chemistry
Issue number6
StatePublished - Nov 2021
Externally publishedYes


  • CD86
  • family B7
  • immunotherapy
  • oncological diseases
  • phage display

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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