Scaffolded DNA origami of a DNA tetrahedron molecular container

Yonggang Ke, Jaswinder Sharma, Minghui Liu, Kasper Jahn, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

283 Scopus citations


We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10 -23 and 1.5 × 10 -23 m 3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.

Original languageEnglish (US)
Pages (from-to)2445-2447
Number of pages3
JournalNano Letters
Issue number6
StatePublished - Jun 10 2009

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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