Scaffolded DNA origami of a DNA tetrahedron molecular container

Yonggang Ke; Jaswinder Sharma; Minghui Liu; Kasper Jahn; Yan Liu; Hao Yan

doi:10.1021/nl901165f

Scaffolded DNA origami of a DNA tetrahedron molecular container

Yonggang Ke, Jaswinder Sharma, Minghui Liu, Kasper Jahn, Yan Liu, Hao Yan

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283 Scopus citations

Abstract

We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10 ^-23 and 1.5 × 10 ^-23 m ³, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.

Original language	English (US)
Pages (from-to)	2445-2447
Number of pages	3
Journal	Nano Letters
Volume	9
Issue number	6
DOIs	https://doi.org/10.1021/nl901165f
State	Published - Jun 10 2009

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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abstract = "We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10 -23 and 1.5 × 10 -23 m 3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.",

author = "Yonggang Ke and Jaswinder Sharma and Minghui Liu and Kasper Jahn and Yan Liu and Hao Yan",

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T1 - Scaffolded DNA origami of a DNA tetrahedron molecular container

AU - Ke, Yonggang

AU - Sharma, Jaswinder

AU - Liu, Minghui

AU - Jahn, Kasper

AU - Liu, Yan

AU - Yan, Hao

PY - 2009/6/10

Y1 - 2009/6/10

N2 - We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10 -23 and 1.5 × 10 -23 m 3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.

AB - We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10 -23 and 1.5 × 10 -23 m 3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.

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JO - Nano Letters

JF - Nano Letters

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Scaffolded DNA origami of a DNA tetrahedron molecular container

Abstract

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