Safety and Efficacy of Acamprosate for the Treatment of Alcohol Dependence

Stephanie L. Yahn, Lucas R. Watterson, M. Foster Olive

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Acamprosate (calcium acetylhomotaurine) is an amino acid modulator that has displayed efficacy in some clinical trials in reducing craving and promoting abstinence in alcohol dependent patients following detoxification. While acamprosate is safe and generally well-tolerated, not all studies have demonstrated clinical efficacy that is superior to placebo. In addition, the precise neurochemical mechanisms of action of acamprosate have still not yet been identified. In this review, we summarize current clinical data on the safety, efficacy, and pharmacokinetic properties of acamprosate, as well theories on its potential mechanism of action. We also discuss tolerability and patient preference issues and conclude with a discussion of the place of acamprosate in addiction medicine and therapy.

Original languageEnglish (US)
JournalSubstance Abuse: Research and Treatment
StatePublished - Jan 2013
Externally publishedYes


  • acamprosate
  • alcoholism
  • amino acid
  • craving
  • dependence
  • glutamate
  • pharmacotherapy

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Safety and Efficacy of Acamprosate for the Treatment of Alcohol Dependence'. Together they form a unique fingerprint.

Cite this