Room-temperature detection of a single 19nm super-paramagnetic nanoparticle with an imaging magnetometer

Michael Gould; Russell J. Barbour; Nicole Thomas; Hamed Arami; Kannan M. Krishnan; Kai Mei C. Fu

doi:10.1063/1.4893602

Room-temperature detection of a single 19nm super-paramagnetic nanoparticle with an imaging magnetometer

Michael Gould, Russell J. Barbour, Nicole Thomas, Hamed Arami, Kannan M. Krishnan, Kai Mei C. Fu

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We demonstrate room temperature detection of isolated single 19nm super-paramagnetic nanoparticles (SPNs) with a wide-field optical microscope platform suitable for biological integration. The particles are made of magnetite (Fe₃O₄) and are thus non-toxic and biocompatible. Detection is accomplished via optically detected magnetic resonance imaging using nitrogen-vacancy defect centers in diamond, resulting in a DC magnetic field detection limit of 2.4μT. This marks a large step forward in the detection of SPNs, and we expect that it will allow for the development of magnetic-field-based biosensors capable of detecting a single molecular binding event.

Original language	English (US)
Article number	072406
Journal	Applied Physics Letters
Volume	105
Issue number	7
DOIs	https://doi.org/10.1063/1.4893602
State	Published - Aug 18 2014
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4893602

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title = "Room-temperature detection of a single 19nm super-paramagnetic nanoparticle with an imaging magnetometer",

abstract = "We demonstrate room temperature detection of isolated single 19nm super-paramagnetic nanoparticles (SPNs) with a wide-field optical microscope platform suitable for biological integration. The particles are made of magnetite (Fe3O4) and are thus non-toxic and biocompatible. Detection is accomplished via optically detected magnetic resonance imaging using nitrogen-vacancy defect centers in diamond, resulting in a DC magnetic field detection limit of 2.4μT. This marks a large step forward in the detection of SPNs, and we expect that it will allow for the development of magnetic-field-based biosensors capable of detecting a single molecular binding event.",

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AU - Barbour, Russell J.

AU - Thomas, Nicole

AU - Arami, Hamed

AU - Krishnan, Kannan M.

AU - Fu, Kai Mei C.

PY - 2014/8/18

Y1 - 2014/8/18

N2 - We demonstrate room temperature detection of isolated single 19nm super-paramagnetic nanoparticles (SPNs) with a wide-field optical microscope platform suitable for biological integration. The particles are made of magnetite (Fe3O4) and are thus non-toxic and biocompatible. Detection is accomplished via optically detected magnetic resonance imaging using nitrogen-vacancy defect centers in diamond, resulting in a DC magnetic field detection limit of 2.4μT. This marks a large step forward in the detection of SPNs, and we expect that it will allow for the development of magnetic-field-based biosensors capable of detecting a single molecular binding event.

AB - We demonstrate room temperature detection of isolated single 19nm super-paramagnetic nanoparticles (SPNs) with a wide-field optical microscope platform suitable for biological integration. The particles are made of magnetite (Fe3O4) and are thus non-toxic and biocompatible. Detection is accomplished via optically detected magnetic resonance imaging using nitrogen-vacancy defect centers in diamond, resulting in a DC magnetic field detection limit of 2.4μT. This marks a large step forward in the detection of SPNs, and we expect that it will allow for the development of magnetic-field-based biosensors capable of detecting a single molecular binding event.

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Room-temperature detection of a single 19nm super-paramagnetic nanoparticle with an imaging magnetometer

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