TY - GEN
T1 - Role of biofunctionalization and tracer cross-linking in magnetic particle spectrometry
AU - Arami, Hamed
AU - Ferguson, R. M.
AU - Khandhar, Amit P.
AU - Tomitaka, Asahi
AU - Krishnan, Kannan M.
PY - 2013
Y1 - 2013
N2 - Both PEGylated NPs were highly stable in biological media, with sustained long-term (tested up to 1 week) signal intensity and half-width in their magnetic particle spectrometry (MPS). However, the terminating functional groups of the PEG molecules altered the efficacy of the phase transfer, polydispersity index (PDI) of their hydrodynamic size (dH) and the MPs signal. When NH 2-PEG-SH was used for PEGylation of the NPs, the PDI (= 0.124), dH (=41nm) and Particle Response Function (PRF) peak width (see Figures b and c) were smaller, in comparison with NH2-PEG-NH2 (PDI = 0.213, dH = 110nm).
AB - Both PEGylated NPs were highly stable in biological media, with sustained long-term (tested up to 1 week) signal intensity and half-width in their magnetic particle spectrometry (MPS). However, the terminating functional groups of the PEG molecules altered the efficacy of the phase transfer, polydispersity index (PDI) of their hydrodynamic size (dH) and the MPs signal. When NH 2-PEG-SH was used for PEGylation of the NPs, the PDI (= 0.124), dH (=41nm) and Particle Response Function (PRF) peak width (see Figures b and c) were smaller, in comparison with NH2-PEG-NH2 (PDI = 0.213, dH = 110nm).
UR - http://www.scopus.com/inward/record.url?scp=84880972151&partnerID=8YFLogxK
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U2 - 10.1109/IWMPI.2013.6528378
DO - 10.1109/IWMPI.2013.6528378
M3 - Conference contribution
AN - SCOPUS:84880972151
SN - 9781467355223
T3 - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
BT - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
T2 - 2013 International Workshop on Magnetic Particle Imaging, IWMPI 2013
Y2 - 23 March 2013 through 24 March 2013
ER -