TY - JOUR
T1 - Region-specific involvement of AMPA/Kainate receptors in Fos protein expression induced by cocaine-conditioned cues
AU - Zavala, Arturo R.
AU - Browning, Jenny R.
AU - Dickey, Erin D.
AU - Biswas, Sudipta
AU - Neisewander, Janet
N1 - Funding Information:
Funding for this study was provided by NIDA Grant DA 13649. NIDA had no further role in study design, in the collection, analysis and interpretation of the data, in the writing of the report, or in the decision to submit the paper for publication.
PY - 2008/8
Y1 - 2008/8
N2 - This study investigated the effects of the AMPA/Kainate receptor antagonist, NBQX, on cue-elicited cocaine-seeking behavior and concomitant changes in Fos protein expression. After cocaine self-administration training, rats underwent 24 days of abstinence during which they were exposed daily either to the self-administration environment with response-contingent cues previously paired with cocaine infusions available (Extinction group) or to an alternate environment (No Extinction group). Subsequently, rats were tested for cocaine-seeking behavior (i.e., operant responses without cocaine reinforcement) elicited by the cocaine-associated cues after pretreatment with either vehicle or NBQX (10 mg/kg, IP). NBQX markedly attenuated cue-elicited cocaine-seeking behavior relative to vehicle pretreatment in the No Extinction group and also decreased cue-elicited Fos protein expression in a region-specific manner in the anterior cingulate and orbitofrontal cortices, basolateral amygdala, nucleus accumbens core, and dorsal caudate-putamen, suggesting involvement of AMPA glutamate systems in specific subregions of the neuronal circuitry activated by cocaine cues.
AB - This study investigated the effects of the AMPA/Kainate receptor antagonist, NBQX, on cue-elicited cocaine-seeking behavior and concomitant changes in Fos protein expression. After cocaine self-administration training, rats underwent 24 days of abstinence during which they were exposed daily either to the self-administration environment with response-contingent cues previously paired with cocaine infusions available (Extinction group) or to an alternate environment (No Extinction group). Subsequently, rats were tested for cocaine-seeking behavior (i.e., operant responses without cocaine reinforcement) elicited by the cocaine-associated cues after pretreatment with either vehicle or NBQX (10 mg/kg, IP). NBQX markedly attenuated cue-elicited cocaine-seeking behavior relative to vehicle pretreatment in the No Extinction group and also decreased cue-elicited Fos protein expression in a region-specific manner in the anterior cingulate and orbitofrontal cortices, basolateral amygdala, nucleus accumbens core, and dorsal caudate-putamen, suggesting involvement of AMPA glutamate systems in specific subregions of the neuronal circuitry activated by cocaine cues.
KW - Addiction
KW - Conditioning
KW - Drug craving
KW - Immediate early gene
KW - Incentive motivation
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UR - http://www.scopus.com/inward/citedby.url?scp=45849106486&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2008.04.010
DO - 10.1016/j.euroneuro.2008.04.010
M3 - Article
C2 - 18539009
AN - SCOPUS:45849106486
SN - 0924-977X
VL - 18
SP - 600
EP - 611
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 8
ER -