Recombinant immune complexes as vaccines against infectious diseases

Mi Young Kim, Hugh S. Mason, Julian K.C. Ma, Rajko Reljic

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

New vaccine technologies are needed to combat many existing infections and prepare better for those that may emerge in the future. The conventional technologies that rely on protein-based vaccines are still severely restricted by the sparsity and poor accessibility of available adjuvants. One possible solution to this problem is to enhance antigen immunogenicity by a more natural means by complexing it with antibodies in the form of immune complexes (ICs). However, natural ICs are impractical as vaccines, and significant research efforts have been made to generate them in recombinant form, with plant bioengineering being at the forefront of these efforts. Here, we describe the challenges and progress made to date to make recombinant IC vaccines applicable to humans.

Original languageEnglish (US)
Pages (from-to)1427-1438
Number of pages12
JournalTrends in Biotechnology
Volume42
Issue number11
DOIs
StatePublished - Nov 2024

Keywords

  • immune complexes
  • infection
  • plants
  • vaccines

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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