Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses

Kemal Karaca; Jagdev M. Sharma; Barbara J. Winslow; David E. Junker; Sudhir Reddy; Mark Cochran; Janis McMillen

doi:10.1016/S0264-410X(97)00295-8

Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses

Kemal Karaca
, Jagdev M. Sharma
, Barbara J. Winslow
, David E. Junker
, Sudhir Reddy
, Mark Cochran
, Janis McMillen

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

We have constructed recombinant (r) fowl pox viruses (FPVs) coexpressing chicken type I interferon (IFN) and/or hemagglutinin-neuraminidase (HN) and fusion (F) proteins of Newcastle disease virus (NDV). We administered rFPVs and FPV into embryonated chicken eggs at 17 days of embryonation or in chickens after hatch. Administration of FPV or rFPVs did not influence hatchability and survival of hatched chicks. In ovo or after hatch vaccination of chickens with the recombinant viruses resulted in protection against challenge with virulent FPV and NDL7. Chickens vaccinated with FPV or FPV-NDV recombinant had significantly lower body weight 2 weeks following vaccination. This loss in body weight was not detected in chickens receiving FPV-IFN and FPV-NDV-IFN recombinants. Chickens vaccinated with FPV coexpressing IFN and NDV genes produced less antibodies against NDV in comparison with chickens vaccinated with FPV expressing NDV genes.

Original language	English (US)
Pages (from-to)	1496-1503
Number of pages	8
Journal	Vaccine
Volume	16
Issue number	16
DOIs	https://doi.org/10.1016/S0264-410X(97)00295-8
State	Published - Oct 1998
Externally published	Yes

Keywords

Chicken
Hemagglutinin- neuraminidase of Newcastle disease virus
In ovo
Recombinant fowlpox virus
Type I interferon

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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Karaca, K., Sharma, J. M., Winslow, B. J., Junker, D. E., Reddy, S., Cochran, M., & McMillen, J. (1998). Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses. Vaccine, 16(16), 1496-1503. https://doi.org/10.1016/S0264-410X(97)00295-8

Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses. / Karaca, Kemal; Sharma, Jagdev M.; Winslow, Barbara J. et al.
In: Vaccine, Vol. 16, No. 16, 10.1998, p. 1496-1503.

Research output: Contribution to journal › Article › peer-review

Karaca, K, Sharma, JM, Winslow, BJ, Junker, DE, Reddy, S, Cochran, M & McMillen, J 1998, 'Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses', Vaccine, vol. 16, no. 16, pp. 1496-1503. https://doi.org/10.1016/S0264-410X(97)00295-8

Karaca K, Sharma JM, Winslow BJ, Junker DE, Reddy S, Cochran M et al. Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses. Vaccine. 1998 Oct;16(16):1496-1503. doi: 10.1016/S0264-410X(97)00295-8

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title = "Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses",

abstract = "We have constructed recombinant (r) fowl pox viruses (FPVs) coexpressing chicken type I interferon (IFN) and/or hemagglutinin-neuraminidase (HN) and fusion (F) proteins of Newcastle disease virus (NDV). We administered rFPVs and FPV into embryonated chicken eggs at 17 days of embryonation or in chickens after hatch. Administration of FPV or rFPVs did not influence hatchability and survival of hatched chicks. In ovo or after hatch vaccination of chickens with the recombinant viruses resulted in protection against challenge with virulent FPV and NDL7. Chickens vaccinated with FPV or FPV-NDV recombinant had significantly lower body weight 2 weeks following vaccination. This loss in body weight was not detected in chickens receiving FPV-IFN and FPV-NDV-IFN recombinants. Chickens vaccinated with FPV coexpressing IFN and NDV genes produced less antibodies against NDV in comparison with chickens vaccinated with FPV expressing NDV genes.",

keywords = "Chicken, Hemagglutinin- neuraminidase of Newcastle disease virus, In ovo, Recombinant fowlpox virus, Type I interferon",

author = "Kemal Karaca and Sharma, \{Jagdev M.\} and Winslow, \{Barbara J.\} and Junker, \{David E.\} and Sudhir Reddy and Mark Cochran and Janis McMillen",

year = "1998",

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doi = "10.1016/S0264-410X(97)00295-8",

language = "English (US)",

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AU - Karaca, Kemal

AU - Sharma, Jagdev M.

AU - Winslow, Barbara J.

AU - Junker, David E.

AU - Reddy, Sudhir

AU - Cochran, Mark

AU - McMillen, Janis

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N2 - We have constructed recombinant (r) fowl pox viruses (FPVs) coexpressing chicken type I interferon (IFN) and/or hemagglutinin-neuraminidase (HN) and fusion (F) proteins of Newcastle disease virus (NDV). We administered rFPVs and FPV into embryonated chicken eggs at 17 days of embryonation or in chickens after hatch. Administration of FPV or rFPVs did not influence hatchability and survival of hatched chicks. In ovo or after hatch vaccination of chickens with the recombinant viruses resulted in protection against challenge with virulent FPV and NDL7. Chickens vaccinated with FPV or FPV-NDV recombinant had significantly lower body weight 2 weeks following vaccination. This loss in body weight was not detected in chickens receiving FPV-IFN and FPV-NDV-IFN recombinants. Chickens vaccinated with FPV coexpressing IFN and NDV genes produced less antibodies against NDV in comparison with chickens vaccinated with FPV expressing NDV genes.

AB - We have constructed recombinant (r) fowl pox viruses (FPVs) coexpressing chicken type I interferon (IFN) and/or hemagglutinin-neuraminidase (HN) and fusion (F) proteins of Newcastle disease virus (NDV). We administered rFPVs and FPV into embryonated chicken eggs at 17 days of embryonation or in chickens after hatch. Administration of FPV or rFPVs did not influence hatchability and survival of hatched chicks. In ovo or after hatch vaccination of chickens with the recombinant viruses resulted in protection against challenge with virulent FPV and NDL7. Chickens vaccinated with FPV or FPV-NDV recombinant had significantly lower body weight 2 weeks following vaccination. This loss in body weight was not detected in chickens receiving FPV-IFN and FPV-NDV-IFN recombinants. Chickens vaccinated with FPV coexpressing IFN and NDV genes produced less antibodies against NDV in comparison with chickens vaccinated with FPV expressing NDV genes.

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KW - Hemagglutinin- neuraminidase of Newcastle disease virus

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KW - Recombinant fowlpox virus

KW - Type I interferon

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Recombinant fowlpox viruses coexpressing chicken type I IFN and newcastle disease virus HN and F genes: Influence of IFN on protective efficacy and humoral responses of chickens following in ovo or post-hatch administration of recombinant viruses

Abstract

Keywords

ASJC Scopus subject areas

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