Recent studies of ribonuclease P

Sidney Altman, Leif Kirsebom, Simon Talbot

Research output: Contribution to journalReview articlepeer-review

155 Scopus citations


RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalFASEB Journal
Issue number1
StatePublished - Jan 1993
Externally publishedYes


  • Catalytic RNA
  • Phylogenetic comparisons
  • RNA-protein interactions
  • tRNA biosynthesis

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry
  • Biotechnology


Dive into the research topics of 'Recent studies of ribonuclease P'. Together they form a unique fingerprint.

Cite this