TY - JOUR
T1 - Programming nanoparticle valence bonds with single-stranded DNA encoders
AU - Yao, Guangbao
AU - Li, Jiang
AU - Li, Qian
AU - Chen, Xiaoliang
AU - Liu, Xiaoguo
AU - Wang, Fei
AU - Qu, Zhibei
AU - Ge, Zhilei
AU - Narayanan, Raghu Pradeep
AU - Williams, Dewight
AU - Pei, Hao
AU - Zuo, Xiaolei
AU - Wang, Lihua
AU - Yan, Hao
AU - Feringa, Ben L.
AU - Fan, Chunhai
N1 - Funding Information:
This work was financially supported by the National Key R&D Program of China (2016YFA0201200), National Natural Science Foundation of China (21834007, 21675167, 31571014, U1532119, 21775157, 11575278), the National Science Foundation (1531991), China Postdoctoral Science Foundation (2015M580373, 2016T90396), the Open Large Infrastructure Research of the Chinese Academy of Sciences, the LU JIAXI International team programme supported by CAS and the K.C. Wong Education Foundation, Shanghai Jiao Tong University. The authors are also thankful for the staff from BL19U2 beamline of National Facility for Protein Science Shanghai (NFPS) at Shanghai Synchrotron Radiation Facility (SSRF) for assistance during data collection.
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Nature has evolved strategies to encode information within a single biopolymer to program biomolecular interactions with characteristic stoichiometry, orthogonality and reconfigurability. Nevertheless, synthetic approaches for programming molecular reactions or assembly generally rely on the use of multiple polymer chains (for example, patchy particles). Here we demonstrate a method for patterning colloidal gold nanoparticles with valence bond analogues using single-stranded DNA encoders containing polyadenine (polyA). By programming the order, length and sequence of each encoder with alternating polyA/non-polyA domains, we synthesize programmable atom-like nanoparticles (PANs) with n-valence that can be used to assemble a spectrum of low-coordination colloidal molecules with different composition, size, chirality and linearity. Moreover, by exploiting the reconfigurability of PANs, we demonstrate dynamic colloidal bond-breaking and bond-formation reactions, structural rearrangement and even the implementation of Boolean logic operations. This approach may be useful for generating responsive functional materials for distinct technological applications.
AB - Nature has evolved strategies to encode information within a single biopolymer to program biomolecular interactions with characteristic stoichiometry, orthogonality and reconfigurability. Nevertheless, synthetic approaches for programming molecular reactions or assembly generally rely on the use of multiple polymer chains (for example, patchy particles). Here we demonstrate a method for patterning colloidal gold nanoparticles with valence bond analogues using single-stranded DNA encoders containing polyadenine (polyA). By programming the order, length and sequence of each encoder with alternating polyA/non-polyA domains, we synthesize programmable atom-like nanoparticles (PANs) with n-valence that can be used to assemble a spectrum of low-coordination colloidal molecules with different composition, size, chirality and linearity. Moreover, by exploiting the reconfigurability of PANs, we demonstrate dynamic colloidal bond-breaking and bond-formation reactions, structural rearrangement and even the implementation of Boolean logic operations. This approach may be useful for generating responsive functional materials for distinct technological applications.
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U2 - 10.1038/s41563-019-0549-3
DO - 10.1038/s41563-019-0549-3
M3 - Article
C2 - 31873228
AN - SCOPUS:85077162256
SN - 1476-1122
VL - 19
SP - 781
EP - 788
JO - Nature materials
JF - Nature materials
IS - 7
ER -