Primary sclerosing cholangitis: Evolving concepts in diagnosis and treatment

Denise M. Harnois, Keith D. Lindor

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Primary sclerosing cholangitis is an increasingly recognized cause of chronic cholestatic liver disease. The etiology is unknown, although a number of immunologic and nonimmunologic factors have been considered. The most important diagnostic findings are diffuse irregularity and narrowing of extrahepatic and intrahepatic bile ducts. The prognosis varies, and a number of relatively unique complications may develop. No adequate treatment exists, although a number of potential treatments have been evaluated. Liver transplantation still remains the most appropriate treatment for end-stage disease. These various topics related to primary sclerosing cholangitis are reviewed.

Original languageEnglish (US)
Pages (from-to)23-41
Number of pages19
JournalDigestive Diseases
Issue number1-2
StatePublished - Jan 1 1997
Externally publishedYes


  • Diagnosis
  • Management
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology


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