Phasing of coherent femtosecond X-ray diffraction from size-varying nanocrystals

John Spence, Richard Kirian, Xiaoyu Wang, Uwe Weierstall, Kevin Schmidt, Thomas White, Anton Barty, Henry N. Chapman, Stefano Marchesini, James Holton

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


The scattering between Bragg reflections from nanocrystals is used to aid solution of the phase problem. We describe a method for reconstructing the charge density of a typical molecule within a single unit cell, if sufficiently finely-sampled "snap-shot" diffraction data (as provided a free-electron X-ray laser) are available from many nanocrystals of different sizes lying in random orientations. By using information on the particle-size distribution within the patterns, this digital method succeeds, using all the data, without knowledge of the distribution of particle size or requiring atomic-resolution data.

Original languageEnglish (US)
Pages (from-to)2866-2873
Number of pages8
JournalOptics Express
Issue number4
StatePublished - Feb 14 2011

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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