Pharmacological treatment of biliary cirrhosis with ursodeoxycholic acid

Ghulam Abbas, Keith D. Lindor

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Importance of the field: Primary biliary cirrhosis is a cholestatic liver disease that at one time was the leading indication for liver transplantation. Treatment with ursodeoxycholic acid has clearly improved the natural history of primary biliary cirrhosis. Areas covered in this review: The treatment of primary biliary cirrhosis with a focus on ursodeoxycholic acid is covered. Papers related to treatment of primary biliary cirrhosis and associated conditions, using a variety of drugs but with a focus on ursodeoxycholic acid, are included. The papers reviewed date from 1984 2009. What will the reader gain: The reader will gain an up-to-date understanding of current treatment strategies for primary biliary cirrhosis using ursodeoxycholic acid and an appreciation of what conditions are improved with this therapy and what associated conditions are not. Take-home message: Ursodeoxycholic acid in a dose of 13 15 mg/kg/day should be considered in all patients with primary biliary cirrhosis who have abnormal liver enzymes.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalExpert Opinion on Pharmacotherapy
Issue number3
StatePublished - Feb 2010
Externally publishedYes


  • Liver disease
  • Primary biliary cirrhosis
  • Therapy
  • Ursodeoxycholic acid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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