Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Zuzana Nedelska, Tanis J. Ferman, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Melissa E. Murray, Jeffrey L. Gunter, Matthew L. Senjem, Prashanti Vemuri, Glenn E. Smith, Yonas E. Geda, Jonathan Graff-Radford, David S. Knopman, Ronald C. Petersen, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We investigated the pattern and magnitude of the atrophy rates from 2 serial MRIs in autopsy-confirmed DLB patients (n = 20) and mixed DLB/AD patients (n = 22), compared with AD (n = 30) and elderly nondemented control subjects (n = 15), followed antemortem. DLB patients without significant AD-type pathology were characterized by lower global and regional rates of atrophy, similar to control subjects. The mixed DLB/AD patients displayed greater atrophy rates in the whole brain, temporoparietal cortices, hippocampus and amygdala, and ventricle expansion, similar to AD patients. In the DLB and DLB/AD patients, the atrophy rates correlated with Braak neurofibrillary tangle stage, cognitive decline, and progression of motor symptoms. Global and regional atrophy rates are associated with AD-type pathology in DLB, and these rates can be used as biomarkers of AD progression in patients with LB pathology.

Original languageEnglish (US)
Pages (from-to)452-461
Number of pages10
JournalNeurobiology of Aging
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes


  • Alzheimer's disease
  • Atrophy rate
  • Autopsy-confirmed dementia with Lewy bodies
  • Braak neurofibrillary tangle stage
  • Sample size estimate
  • Serial MRI

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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