Oxidative Stress and Antioxidant-Supplementation in the Management of Diabetic Cardiovascular Disease

Sonia Vega-López, Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation, increased F 2-isoprostanes, increased nitrotyrosine, and increased DNA-damage. Also, in diabetics, there is increased superoxide release. With regard to diabetes, antioxidants such as α-tocopherol α-lipoate, and ascorbic acid supplementation have been shown to be beneficial. Most importantly, α-tocopherol therapy, especially at high doses, clearly shows a benefit with regard to low-density lipoprotein oxidation, isoprostanes, and monocyte superoxide release. Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalJournal of Investigative Medicine
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Antioxidant
  • Diabetes
  • Isoprostane
  • Oxidation
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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