Overview of serpins and their roles in biological systems

Alexandra Lucas, Jordan R. Yaron, Liqiang Zhang, Sriram Ambadapadi

Research output: Chapter in Book/Report/Conference proceedingChapter

38 Scopus citations


Serine protease inhibitors are ubiquitous regulators for a multitude of pathways in humans. The serpins represent an ancient pathway now known to be present in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man. Serpins have been present from the time of the dinosaurs and can represent a large proportion of circulating blood proteins. With this introductory chapter, we present an overview of serpins as well as an introduction and overview of the chapters describing the methodology used in the new approaches to understanding their molecular mechanisms of action and their roles in health and disease.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages7
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Bacteria
  • Crystallography
  • Inflammation
  • Kinetics
  • Malaria
  • Microbiome
  • Neurotrauma
  • Peptides
  • Phage
  • Serpin
  • Serpinopathy
  • Thrombosis
  • Trypsin
  • Virus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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