Opiate control of spontaneous locomotor activity in a urodele amphibian

Pierre Deviche; Christopher A. Lowry; Frank L. Moore

doi:10.1016/0091-3057(89)90270-0

Opiate control of spontaneous locomotor activity in a urodele amphibian

Pierre Deviche, Christopher A. Lowry, Frank L. Moore

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

An intraperitoneal injection of the preferential opiate receptor agonist (±)bremazocine HCl given to male rough-skinned newts acutely and dose-dependently reduced their spontaneous locomotor activity. Inversely, and contrary to the situation generally observed in other vertebrates, administration of the opiate receptor antagonist naloxone HCl dose-dependently and acutely stimulated locomotion. Given at a behaviorally active dosage, naloxone counteracted the inhibitory effect of bremazocine on locomotion. The behavioral influence of the two substances was observed using two different sampling techniques (continuous recording for 3 minutes; repeated instantaneous sampling for 60 minutes). These data are discussed in view of our current knowledge on the opiate regulation of locomotor activity in vertebrates.

Original language	English (US)
Pages (from-to)	753-757
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(89)90270-0
State	Published - Dec 1989
Externally published	Yes

Keywords

Amphibians
Bremazocine
Locomotion
Naloxone
Opiates

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(89)90270-0

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title = "Opiate control of spontaneous locomotor activity in a urodele amphibian",

abstract = "An intraperitoneal injection of the preferential opiate receptor agonist (±)bremazocine HCl given to male rough-skinned newts acutely and dose-dependently reduced their spontaneous locomotor activity. Inversely, and contrary to the situation generally observed in other vertebrates, administration of the opiate receptor antagonist naloxone HCl dose-dependently and acutely stimulated locomotion. Given at a behaviorally active dosage, naloxone counteracted the inhibitory effect of bremazocine on locomotion. The behavioral influence of the two substances was observed using two different sampling techniques (continuous recording for 3 minutes; repeated instantaneous sampling for 60 minutes). These data are discussed in view of our current knowledge on the opiate regulation of locomotor activity in vertebrates.",

keywords = "Amphibians, Bremazocine, Locomotion, Naloxone, Opiates",

author = "Pierre Deviche and Lowry, {Christopher A.} and Moore, {Frank L.}",

note = "Funding Information: This research was supported by National Institute of Health Research Grant R01 HD13508, and a N.A.T.O. Research Fellowship to P.D.",

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T1 - Opiate control of spontaneous locomotor activity in a urodele amphibian

AU - Deviche, Pierre

AU - Lowry, Christopher A.

AU - Moore, Frank L.

N1 - Funding Information: This research was supported by National Institute of Health Research Grant R01 HD13508, and a N.A.T.O. Research Fellowship to P.D.

PY - 1989/12

Y1 - 1989/12

N2 - An intraperitoneal injection of the preferential opiate receptor agonist (±)bremazocine HCl given to male rough-skinned newts acutely and dose-dependently reduced their spontaneous locomotor activity. Inversely, and contrary to the situation generally observed in other vertebrates, administration of the opiate receptor antagonist naloxone HCl dose-dependently and acutely stimulated locomotion. Given at a behaviorally active dosage, naloxone counteracted the inhibitory effect of bremazocine on locomotion. The behavioral influence of the two substances was observed using two different sampling techniques (continuous recording for 3 minutes; repeated instantaneous sampling for 60 minutes). These data are discussed in view of our current knowledge on the opiate regulation of locomotor activity in vertebrates.

AB - An intraperitoneal injection of the preferential opiate receptor agonist (±)bremazocine HCl given to male rough-skinned newts acutely and dose-dependently reduced their spontaneous locomotor activity. Inversely, and contrary to the situation generally observed in other vertebrates, administration of the opiate receptor antagonist naloxone HCl dose-dependently and acutely stimulated locomotion. Given at a behaviorally active dosage, naloxone counteracted the inhibitory effect of bremazocine on locomotion. The behavioral influence of the two substances was observed using two different sampling techniques (continuous recording for 3 minutes; repeated instantaneous sampling for 60 minutes). These data are discussed in view of our current knowledge on the opiate regulation of locomotor activity in vertebrates.

KW - Amphibians

KW - Bremazocine

KW - Locomotion

KW - Naloxone

KW - Opiates

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ER -

Opiate control of spontaneous locomotor activity in a urodele amphibian

Abstract

Keywords

ASJC Scopus subject areas

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