Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2

Keyphrases

• MEK1 100%
• Intestinal Epithelial Cells 100%
• Cyclooxygenase-2 100%
• Oncogenic Potential 100%
• Constitutively Active 40%
• Induced Apoptosis 20%
• Tumor Growth in Vivo 20%
• Soft Agar 20%
• MEK Signaling 20%
• Signaling Cascades 10%
• Cell Growth 10%
• Cell Systems 10%
• Tumor 10%
• Colorectal Cancer 10%
• Transcriptional Activity 10%
• Cell Differentiation 10%
• Two-level 10%
• Apoptosis 10%
• Nude Mice 10%
• Mitogen-activated Protein Kinase 10%
• Post-transcriptional 10%
• Active Components 10%
• Pharmacological Inhibitors 10%
• Oncogenic Transformation 10%
• Transient Transfection 10%
• Prostaglandin E2 10%
• Celecoxib 10%
• Bioactive Lipids 10%
• Northern Blot Analysis 10%
• Decreased Expression 10%
• Bcl-xL 10%
• Cell Cycle Arrest 10%
• Xenografted Mice 10%
• Annexin V Assay 10%
• Extracellular Regulated Protein Kinases 10%
• Induced Transformations 10%
• Sodium Butyrate 10%
• Soft Tissue Tumor 10%
• Myeloid Cell leukemia-1 (Mcl-1) 10%
• MEK Pathway 10%
• IEC-6 Cells 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Cyclooxygenase 2 100%
• Neoplasm 20%
• Tumor Growth 20%
• Agar 20%
• Protein Kinases 10%
• Phosphotransferase 10%
• Nude Mouse 10%
• Celecoxib 10%
• Colorectal Carcinoma 10%
• Mitogen Activated Protein Kinase 10%
• Lipocortin 5 10%
• Butyrate 10%

Biochemistry, Genetics and Molecular Biology

• Celecoxib 10%