On the prospect of achieving accurate joint estimation of selection with population history

Parul Johri, Adam Eyre-Walker, Ryan N. Gutenkunst, Kirk E. Lohmueller, Jeffrey D. Jensen

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

As both natural selection and population history can affect genome-wide patterns of variation, disentangling the contributions of each has remained as a major challenge in population genetics. We here discuss historical and recent progress towards this goal-highlighting theoretical and computational challenges that remain to be addressed, as well as inherent difficulties in dealing with model complexity and model violations-and offer thoughts on potentially fruitful next steps.

Original languageEnglish (US)
Article numberevac088
JournalGenome biology and evolution
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2022

Keywords

  • background selection
  • demography
  • genetic hitchhiking
  • natural selection
  • population history
  • statistical inference

ASJC Scopus subject areas

  • General Medicine

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