Occipital cortico-pyramidal projection in hypothyroid rats

Chi Pei Li, Jaime F. Olavarria, Bradley E. Greger

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalDevelopmental Brain Research
Issue number2
StatePublished - Nov 21 1995
Externally publishedYes


  • Collateral elimination
  • Pyramidal tract
  • Thyroid hormone
  • Transient projection
  • Visual cortex

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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