Occipital cortico-pyramidal projection in hypothyroid rats

Chi Pei Li; Jaime F. Olavarria; Bradley E. Greger

doi:10.1016/0165-3806(95)00119-X

Occipital cortico-pyramidal projection in hypothyroid rats

Chi Pei Li, Jaime F. Olavarria, Bradley E. Greger

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.

Original language	English (US)
Pages (from-to)	227-234
Number of pages	8
Journal	Developmental Brain Research
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(95)00119-X
State	Published - Nov 21 1995
Externally published	Yes

Keywords

Collateral elimination
Pyramidal tract
Thyroid hormone
Transient projection
Visual cortex

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(95)00119-X

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title = "Occipital cortico-pyramidal projection in hypothyroid rats",

abstract = "It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.",

keywords = "Collateral elimination, Pyramidal tract, Thyroid hormone, Transient projection, Visual cortex",

author = "Li, {Chi Pei} and Olavarria, {Jaime F.} and Greger, {Bradley E.}",

note = "Funding Information: We thank P.L. Abel and B.J. O'Brien for comments on the manuscript and A. Zitzka for assistance with illustrations. This research was supported by the Graduate School Fund, U.W., and by NIH Grant EY09343 to J.F.O..",

year = "1995",

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doi = "10.1016/0165-3806(95)00119-X",

language = "English (US)",

volume = "89",

pages = "227--234",

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T1 - Occipital cortico-pyramidal projection in hypothyroid rats

AU - Li, Chi Pei

AU - Olavarria, Jaime F.

AU - Greger, Bradley E.

N1 - Funding Information: We thank P.L. Abel and B.J. O'Brien for comments on the manuscript and A. Zitzka for assistance with illustrations. This research was supported by the Graduate School Fund, U.W., and by NIH Grant EY09343 to J.F.O..

PY - 1995/11/21

Y1 - 1995/11/21

N2 - It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.

AB - It is well established that the progressive disappearance of a transient occipitospinal projection in neonatal rats involves the selective elimination of axonal collaterals. We studied whether the development of the occipitospinal pathway was affected by hypothyroidism induced by treatment with the goitrogen 6n-propyl-2-thiouracil (PTU) beginning prenatally. Using both anterograde (biocytin and Dil) and retrograde (horseradish peroxidase and Fast Blue) tracing techniques in adult hypothyroid rats, we found that many cells with projections into the pyramidal tract are present in regions of visual cortex that are devoid of such cells in normal adult rats. Our results suggest that hypothyroidism induced by PTU treatment leads to the maintenance of occipitospinal projections that are normally transient.

KW - Collateral elimination

KW - Pyramidal tract

KW - Thyroid hormone

KW - Transient projection

KW - Visual cortex

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M3 - Article

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SN - 0165-3806

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EP - 234

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2

ER -

Occipital cortico-pyramidal projection in hypothyroid rats

Abstract

Keywords

ASJC Scopus subject areas

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