Novel non-suppressing mutants of Escherichia coli tRNATyr su3+

Paul Furdon, Sidney Altman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Several addition and deletion mutations were constructed in the region of the gene for Escherichia coli tRNATyr su3+ corresponding to the dihydrouracil loop of the mature tRNA. None of these resulting mutants had detectable suppressor function compared to the parent gene yet some directed the synthesis of mature tRNA. These latter mutants may affect the ability of the tRNA to be aminoacylated or to interact with the translational machinery on the ribosome.

Original languageEnglish (US)
Pages (from-to)2583-2601
Number of pages19
JournalNucleic acids research
Issue number7
StatePublished - Apr 11 1985
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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