Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention

R. N. DuBois

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Colorectal cancer is the second leading cause of cancer deaths in the United States. Despite proven screening strategies, less than 40% of eligible Americans undergo appropriate screening for colorectal cancer. Research evaluating the underlying defects responsible for hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis has provided insight into some of the molecular mechanisms responsible for familial and sporadic colorectal cancer. The signaling pathways involved in the development of colorectal cancer may provide effective targets for prevention and treatment. These targets include cyclooxygenase-2, peroxisome proliferator activated receptor- δ, peroxisome proliferator activated receptor- γ, transforming growth factor- β receptors, and the inducible-nitric oxide synthase.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalCurrent Opinion in Gastroenterology
Issue number1
StatePublished - Feb 6 2001
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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