Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

Yonas E. Geda, Lon S. Schneider, Laura N. Gitlin, David S. Miller, Gwenn S. Smith, Joanne Bell, Jovier Evans, Michael Lee, Anton Porsteinsson, Krista L. Lanctôt, Paul B. Rosenberg, David L. Sultzer, Paul T. Francis, Henry Brodaty, Prasad P. Padala, Chiadikaobi U. Onyike, Luis Agüera Ortiz, Sonia Ancoli-Israel, Donald L. Bliwise, Jennifer L. MartinMichael V. Vitiello, Kristine Yaffe, Phyllis C. Zee, Nathan Herrmann, Robert A. Sweet, Clive Ballard, Ni A. Khin, Cara Alfaro, Patrick S. Murray, Susan Schultz, Constantine G. Lyketsos

Research output: Contribution to journalArticlepeer-review

261 Scopus citations


Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalAlzheimer's and Dementia
Issue number5
StatePublished - Sep 2013
Externally publishedYes


  • Agitation/aggression
  • Alzheimer's disease
  • Apathy
  • Behavioral and psychological symptoms of dementia
  • Delusions
  • Dementia
  • Depression
  • Hallucinations
  • Mild behavioral impairment
  • Mild cognitive impairment
  • Neuropsychiatric symptoms
  • Psychosis
  • Sleep disorders

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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