Neuron numbers in locus coeruleus do not change with age in fisher 344 rat

G. Goldman, P. D. Coleman

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Counts of neurons in locus coeruleus of Fisher 344 rats of ages from 12 to 32 months showed no loss with advancing age. Species comparisons of age changes in locus coeruleus neuron counts and measures of catecholamine systems suggest that the human and nonhuman primate locus coeruleus shows age changes not seen in rodent locus coeruleus. It is suggested that although rodent models of human aging have value under some circumstances, rodent and primate brain should not be considered equivalent with regard to phenomena related to noradrenergic mechanisms.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeurobiology of Aging
Issue number1
StatePublished - 1981
Externally publishedYes


  • Aging
  • Fisher 344 rat
  • Locus coeruleus
  • Neuron counts
  • Species differences

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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