Neural plasticity: The biological substrate for neurorehabilitation

Zuha Warraich, Jeffrey A. Kleim

Research output: Contribution to journalArticlepeer-review

153 Scopus citations


Decades of basic science have clearly demonstrated the capacity of the central nervous system (CNS) to structurally and functionally adapt in response to experience. The field of neurorehabilitation has begun to use this body of work to develop neurobiologicallyinformed therapies that harness the key behavioral and neural signals that drive neural plasticity. The present review describes how neural plasticity supports both learning in the intact CNS and functional improvement in the damaged or diseased CNS. A pragmatic, interdisciplinary definition of neural plasticity is presented that may be used by both clinical and basic scientists studying neurorehabilitation. Furthermore, a description of howneural plasticity may act to drive different neural strategies underlying functional improvement after CNS injury or disease is provided. The understanding of the relationship between these different neural strategies, mechanisms of neural plasticity, and changes in behavior may facilitate the development of novel, more effective rehabilitation interventions.

Original languageEnglish (US)
Pages (from-to)S208-S219
JournalPM and R
Issue number12 SUPPL
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Neural plasticity: The biological substrate for neurorehabilitation'. Together they form a unique fingerprint.

Cite this